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. Author manuscript; available in PMC: 2019 Dec 5.
Published in final edited form as: Leukemia. 2019 Jun 17;33(8):1835–1850. doi: 10.1038/s41375-019-0512-y

Figure 3. Dynamics of somatic mutation profiles following TKI therapy.

Figure 3.

Five patterns of mutation dynamics are noted according to their longitudinal changes in mutation burden following TKI therapy. Pattern 1 does not show any significant changes but all the cases responded to TKI therapy optimally, implying independence of the clone carrying the mutation from the Ph-positive clone. Pattern 2 represents new acquisition of mutations, associated with treatment failure. Pattern 3 shows a linear relationship between the reduction rate of mutation allele burden and BCR-ABL1 transcript level reduction, implying that this mutation arose from the Ph-positive clone. Modified from Kim et al. [31].