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. 2019 Nov 28;12:291. doi: 10.3389/fnmol.2019.00291

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Copyright © 2019 Gao, Zheng, Ma, Gong, Xia and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overexpression of PKMζ resulted in higher intrinsic excitability in the excitatory neurons in BLA. (A) Sample spikes evoked by current injection showed higher responses in AAV-hSyn-PKMζ-GFP (right) than in AAV-hSyn-GFP (left) to the same current step (20 mV, 100 ms). (B) Current-spike frequency relationship showed higher responses in neurons expressing AAV-hSyn-PKMζ-GFP (blue) than expressing AAV-hSyn-GFP (red). (C) Sample staining of GFP and parvalbumin (PV) in sections from AAV-hSyn-GFP-expressing (left) and AAV-hSyn-PKMζ-GFP-expressing brains (right). Scale bars = 100 μm. (D) Density of neurons that are positive for both GFP and PV is very low. P = 0.1574, N = 5 sections/mice. **P < 0.01.