Figure 5.

Ultrastructural features of mature lymphatic vessels isolated from Relb^−/− and control mice. Mature lymphatic vessels draining the ankle/foot area were isolated from Relb^−/− and littermate control mice and subjected to electron microscopy. Images of the walls and valves of lymphatic vessels from a control and Relb^−/− mouse, in which lymphatic endothelial cells are indicated by E, smooth muscle cells by S, a macrophage by M, a lymphatic valve by V, tight junctions by red arrows, the interstitial elements by green arrows, an endothelial cell at a valve by blue arrows, and the root of valves by black arrows. Representative images were taken from three mice per genotype. Scale bars: 2 μm (top and middle panels); 5 μm (bottom panels).