Table 2.
Differentially Expressed Genes in TNF, Cell Adhesion, Apoptosis, and Tight Junction Signaling Pathways
| KEGG entry no. | Ensembl ID no. | Gene name | RelB shRNA/Ctl (fold) |
|---|---|---|---|
| TNF signaling pathway | |||
| K04734 | ENSRNOG00000007390 | NFKBIA; NF-κB inhibitor α | −1.69 |
| K09028 | ENSRNOG00000042838 | JUNB; transcription factor jun-B | −4.13 |
| K04430 | ENSRNOG00000003834 | MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 (EC:2.7.12.2) | 0.50 |
| K11859 | ENSRNOG00000049517 | TNFAIP3, A20, OTUD7C; tumor necrosis factor-α-induced protein 3 (EC:3.4.19.12) | −1.67 |
| K04379 | ENSRNOG00000008015 | FOS; proto-oncogene protein c-fos | −2.89 |
| K05427 | ENSRNOG00000026805 | CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor | −5.09 |
| K16366 | ENSRNOG00000014361 | EDN1; endothelin-1 | 0.55 |
| K14624 | ENSRNOG00000007159 | CCL2, MCP1; C-C motif chemokine 2 | −1.96 |
| K06490 | ENSRNOG00000020679 | ICAM1; intercellular adhesion molecule 1 | −1.74 |
| K05508 | ENSRNOG00000016326 | CX3CL1, NTT; C-X3-C motif chemokine 1 | −2.16 |
| K02649 | ENSRNOG00000000145 | PIK3R; phosphoinositide-3-kinase, regulatory subunit | 0.66 |
| K04374 | ENSRNOG00000017801 | ATF4, CREB2; cAMP-dependent transcription factor ATF-4 | −1.88 |
| K16060 | ENSRNOG00000005731 | BIRC2_3; baculoviral IAP repeat-containing protein 2/3 | −2.02 |
| K09258 | ENSRNOG00000043416 | BCL3; B-cell CLL/lymphoma protein 3 | −4.55 |
| K05419 | ENSRNOG00000007002 | LIF; leukemia inhibitory factor | −4.27 |
| K05505 | ENSRNOG00000002802 | CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3 | −1.70 |
| K05505 | ENSRNOG00000002792 | CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3 | −5.29 |
| K05405 | ENSRNOG00000010278 | IL6; IL-6 | −3.25 |
| K04696 | ENSRNOG00000002946 | SOCS3, CIS3; suppressor of cytokine signaling 3 | −2.16 |
| Cell adhesion molecules | |||
| K06590 | ENSRNOG00000012208 | ITGB7; integrin β 7 | −2.05 |
| K06087 | ENSRNOG00000001476 | CLDN; claudin | −1.93 |
| K06087 | ENSRNOG00000001419 | CLDN; claudin | −2.34 |
| K06539 | ENSRNOG00000019202 | PVR, NECL5; poliovirus receptor | −1.50 |
| K06496 | ENSRNOG00000002794 | SELP; selectin, platele | −1.83 |
| K06796 | ENSRNOG00000020129 | CDH3; cadherin 3, type 1, P-cadherin | 0.54 |
| K16359 | ENSRNOG00000013694 | NTNG2; netrin-G2 | −1.90 |
| K06490 | ENSRNOG00000020679 | ICAM1; intercellular adhesion molecule 1 | −1.74 |
| K06464 | ENSRNOG00000001224 | ITGB2; integrin β 2 | −2.28 |
| K06781 | ENSRNOG00000018778 | CADM1, IGSF4, NECL2, TSLC1; cell adhesion molecule 1 | 0.64 |
| K06495 | ENSRNOG00000002776 | SELL; selectin, lymphocyte | −2.74 |
| K16338 | ENSRNOG00000014297 | SDC4; syndecan 4 | −2.01 |
| K03160 | ENSRNOG00000018488 | TNFRSF5, CD40; TNF receptor superfamily member 5 | −2.21 |
| K06470 | ENSRNOG00000010283 | CD28; CD28 antigen | 0.58 |
| Apoptosis | |||
| K04734 | ENSRNOG00000007390 | NFKBIA; NF-κB inhibitor α | −1.69 |
| K04379 | ENSRNOG00000008015 | FOS; proto-oncogene protein c-fos | −2.89 |
| K04402 | ENSRNOG00000005615 | GADD45; growth arrest and DNA damage inducible protein | −2.01 |
| K02649 | ENSRNOG00000000145 | PIK3R; phosphoinositide-3-kinase, regulatory subunit | 0.66 |
| K04374 | ENSRNOG00000017801 | ATF4, CREB2; cAMP-dependent transcription factor ATF-4 | −1.88 |
| K04452 | ENSRNOG00000006789 | DDIT3, GADD153; DNA damage–inducible transcript 3 | −1.65 |
| K16060 | ENSRNOG00000005731 | BIRC2_3; baculoviral IAP repeat-containing protein 2/3 | −2.02 |
| K01379 | ENSRNOG00000020206 | CTSD; cathepsin D (EC:3.4.23.5) | −1.56 |
| K02582 | ENSRNOG00000016571 | NGFB; nerve growth factor, β | −1.60 |
| K04728 | ENSRNOG00000029773 | ATM, TEL1; ataxia telangiectasia mutated family protein (EC:2.7.11.1) | 0.59 |
| Tight junctions | |||
| K06087 | ENSRNOG00000001476 | CLDN; claudin | −1.93 |
| K06087 | ENSRNOG00000001419 | CLDN; claudin | −2.34 |
| K06108 | ENSRNOG00000008001 | RAB3B; Ras-related protein Rab-3B | 0.56 |
| K03456 | ENSRNOG00000010922 | PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A | 0.65 |
| K06101 | ENSRNOG00000020386 | ASH1L; histone-lysine N-methyltransferase ASH1L (EC:2.1.1.43) | 0.66 |
Ctl, control; KEGG, Kyoto Encyclopedia of Genes and Genomes; TNF, tumor necrosis factor.