Table 3.
The Hazard Ratio for Stroke by Atrial Fibrillation Status, eGFR and ACR Levels With eGFR > 90/ACR < 3 and Absence of Atrial Fibrillation as Referent.
| eGFR/ACR | ACR < 3 |
ACR = 3-30 |
ACR > 30 |
|||
|---|---|---|---|---|---|---|
| No AF | AF | No AF | AF | No AF | AF | |
| >90 | Ref | 2.23 (1.78-2.79) | 1.48 (1.06-2.06) | 3.90 (3.02-5.04) | 3.80 (2.52-5.72) | 3.80 (2.47-5.83) |
| 60-90 | 1.38 (1.12-1.71) | 3.36 (2.76-4.11) | 2.18 (1.73-2.74) | 4.51 (3.65-5.56) | 2.65 (1.88-3.72) | 4.93 (3.70-6.58) |
| 45-59 | 1.94 (1.53-2.49) | 3.83 (3.07-4.77) | 2.26 (1.71-2.99) | 4.77 (3.76-6.05) | 2.99 (2.02-4.43) | 4.93 (3.52-6.91) |
| 31-44 | 2.06 (1.55-2.75) | 4.10 (3.20-5.24) | 2.22 (1.61-3.06) | 4.51 (3.45-5.88) | 2.53 (1.60-3.99) | 5.00 (3.47-7.18) |
| ≤30 | 2.54 (1.60-4.04) | 4.27 (2.91-6.28) | 2.68 (1.71-4.21) | 3.03 (1.96-4.69) | 3.25 (1.83-5.76) | 4.40 (2.58-7.51) |
Note. The following variables were included in the propensity score model: year of ACR, time from ACR to index date, sex (male referent), income quintile (lowest quintile referent), location (rural vs urban), and comorbidities at baseline (diabetes mellitus, hypertension, myocardial infarction, congestive heart failure, major hemorrhage, coronary artery disease, coronary revascularization, peripheral artery disease, peripheral vascular disease, and chronic obstructive pulmonary disease). Individuals with AF were greedy matched 1:1 without replacement to non-AF individuals on the logit of the propensity score (±0.05), eGFR and ACR category. P value for the eGFR/ACR level × AF interaction is .04. eGFR = estimated glomerular filtration rate; ACR = albumin-to-creatinine ratio; AF = atrial fibrillation.