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. 2019 Nov 28;7:303. doi: 10.3389/fcell.2019.00303

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Copyright © 2019 Nascimento, Saia-Cereda, Sartore, Madeiro da Costa, Schitine, Freitas, Murgu, de Melo Reis, Rehen and Martins-de-Souza.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interactive organization of proteins from 45-day cerebral organoids. (A) Network representation of selected proteins related to neurogenesis, reelin and migration of neurons, and synaptogenesis. Networks are based on the STRING database (https://string-db.org/). (B) Neuronal guidance is overrepresented in 45-day cerebral organoids (FDR 2.05E-15). Enriched signaling pathways include semaphorin interactions (FDR 5.14E-4), L1CAM interactions (FDR 9.68E-7), signaling by ROBO receptor (FDR 4.9E-9) and Eph-Ephrin signaling (FDR 3.6E-3). Proteins in NCAM signaling for neurite outgrowth, netrin-1, and ret signaling are partially represented. Overrepresentation analyses were performed with Reactome (https://reactome.org/). Proteins found in proteomics analyses of 45-day organoids are colored in shades of blue and green, while gray proteins were not found in the dataset.