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(a) MMI in mice significantly decreases serum miR-126 expression. Compared to miR-126fl/fl mice, miR-126EC−/− mice exhibit significant CBF reduction, and increase in brain inflammatory factor MMP9 and TLR4 gene expression. Compared to miR-126fl/fl mice, miR-126EC−/− mice exhibit significant (b) learning and memory impairment, and (c–d) increased astroglial and microglia activation.
