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. 2016 Oct 25;19(4):460–468. doi: 10.1093/ntr/ntw245

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© The Author 2016. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Figure 2. — Effect of α7 nicotinic acetylcholine receptors (nAChRs) agonist PHA-543613 on disease activity and inflammatory markers in C57Bl/6 male mice with dextran sodium sulfate (DSS) colitis. Effect of chronic daily s.c. treatment of PHA-543613 (2, 8, and 20 mg/kg s.c. twice daily) on (A) time course of disease activity index (DAI). (B) Area under the curve of disease activity. (C) Mean colon length (cm). (D) Colonic tumor necrosis factor-alpha (TNF-α) levels (pg/mg protein) in the homogenized colonic samples. Results are expressed as mean ± SE, n = 6–8, *p < .05 compared to Veh. ^#p < .05 compared to Ctrl (H₂O). Ctrl = water-treated animals; s.c. = subcutaneous; Veh = vehicle DSS-treated mice.