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. 2019 Oct 30;33(12):14588–14601. doi: 10.1096/fj.201901646R

Figure 3.

Figure 3

Purified adiponectin at physiologic concentrations relaxes oxytocin-stimulated contractions in E15 pregnant mouse myometrial strips and stimulates AMPK phosphorylation. A) Contractile tension as AUC is shown for oxytocin-stimulated myometrial strips treated with increasing cumulative concentrations of mouse adiponectin (0.1–10 µg/ml; n = 9) or with the equivalent volume of vehicle (n = 11). Representative tracings are shown in Supplemental Fig. S3. **P < 0.01, ****P < 0.0001. B) Representative blot shows duplicate preparations of adiponectin-treated myometrial strips from organ bath, expressing total AMPK (AMPK) and AMPK phosphorylated at Thr172 (P-thr172-AMPK). Strips were treated with 10 µg/ml adiponectin or equivalent volume of vehicle (n = 4–6 strips). *P < 0.05 vs. vehicle P-thr172-AMPK.