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. 2019 Oct 30;33(12):14588–14601. doi: 10.1096/fj.201901646R

Figure 8.

Figure 8

The direct AMPK activator, A769662, decreases myometrial contractility for oxytocin-induced contractions in E15 and E18 uterine strips. A) Contractile tension as AUC is shown for oxytocin-stimulated E15 (left; n = 6–7) and E18 (right, n = 4) myometrial strips treated with increasing cumulative concentrations of A769662 (1–70 µM) or the equivalent volume of vehicle. *P < 0.05, ***P < 0.001, ****P < 0.0001. B) Representative blots show duplicate preparations of A769662-treated myometrial strips from organ bath, expressing total AMPK (AMPK) and AMPK phosphorylated at Thr172 (P-thr172-AMPK). Strips were treated with 70 µM A769662 or equivalent volume of vehicle. E15 tissues (n = 6–7) and E18 tissues (n = 4). IC50, half maximal inhibition concentration; ns, not significant. **P < 0.01.