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. 2019 Oct 30;33(12):14588–14601. doi: 10.1096/fj.201901646R

Figure 9.

Figure 9

AdipoRon and A769662 decrease myometrial contractility for oxytocin-induced contractions in E15 uterine strips independent of AMPK inhibition and phosphorylation. A) Contractile tension as AUC is shown for oxytocin-stimulated E15 myometrial strips treated with increasing cumulative concentrations of AdipoRon (left, 0.1–40 µM, n = 8–10) and A769662 (right, 1–70 µM, n = 7–9) or the equivalent volume of vehicle in the presence or absence of dorsomorphin (50 µM). *P < 0.05, ****P < 0.0001. B) Representative blots show preparations of AdipoRon- and A769662-treated myometrial strips from organ bath, expressing total AMPK (AMPK) and AMPK phosphorylated at thr172 (P AMPK or P-thr172-AMPK). Strips were treated with 40 µM AdipoRon (n = 12–16) and 70 µM A769662 (n = 8–10) or the equivalent volume of vehicle in presence or absence of 50 µM dorsomorphin. Dorso, dorsomorphin; ns, not significant; Oxy, oxytocin; Veh, vehicle. *P < 0.05, ***P < 0.001.