BI does not affect LPS-mediated increase in permeability-regulating cytokines in the BAL. LPS increases IL-1β (A), IL-6 (B), TNF-α (C), and VEGF-A (D) levels in the BAL. BI neither increases these cytokines nor alters the LPS-mediated increase in the levels of these cytokines. Although substantial amounts of IL-1β and IL-6 are measurable in the serum, levels of these cytokines are not significantly different among the 4 treatment conditions. TNF-α and VEGF-A levels are barely detectable in the serum; n = 5 for each condition. +, mean. **P < 0.01, ***P < 0.001 (P = 0.0781 for LPS vs. BI + LPS for VEGF-A in BAL).