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BI1029539 dosing regimen. BI1029539 (10, 30, 100 mg/kg) or vehicle was administered twice a day via oral gavage over a period of 5 d. Mice received 4 doses of either BI1029539 or vehicle by oral gavage prior to inducing SE in mice and additional 3 applications of either BI1029539 or vehicle after SE induction. Acute SE was induced in both wild-type and transgenic hmPGES-1 mice by fractionated administration of kainic acid.
