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Proposed signaling pathway in brain capillaries. Based on our data presented here and our previously published data, we propose that seizure-induced (Sz) release of glutamate signals through the NMDA receptor (NMDAR), which leads to activation of cPLA2. This, in turn, leads to release of AA, which COX-2 converts to PGH2. mPGES-1 converts PGH2 to PGE2, which signals through EP1, leading to increased P-gp protein expression and transport activity levels at the blood-brain barrier.
