TABLE 1.

Western blot analysis of P-gp protein expression levels in isolated brain capillaries exposed to PGH2 and PGE2

Exposure	P-gp
PGH2
Control	100 ± 2.5
10 nM PGH2	183.7 ± 5.1*
25 nm PGH2	157.1 ± 4.6*
PGE2
Control	100 ± 3.3
0.5 nM PGE2	132.1 ± 4.7*
0.75 nm PGE2	164.2 ± 5.7*
1 nm PGE2	193.4 ± 6.9*

Data were normalized to β-actin levels; values are given as percentage of control ± sem (n = 3). See Fig. 2A, C.

^*P < 0.01 for each endpoint compared with control (Dunnett’s many-to-one t test).