TABLE 5.

Western blot analysis of P-gp and hmPGES-1 protein expression levels in isolated brain capillaries from animals that experienced SE that were treated with BI1029539 or vehicle

Exposure	P-gp	hmPGES-1
Control	100 ± 5.0	100 ± 4.1
100 mg/kg BI1029539	98.7 ± 5.0	108.4 ± 4.3
Kainic acid control	139.0 ± 6.9*	92.9 ± 3.7
SE	190.5 ± 9.4*	146.9 ± 4.8*
SE + 10 mg/kg BI1029539	97.4 ± 4.1	95.6 ± 3.7
SE + 30 mg/kg BI1029539	107.3 ± 4.8	95.1 ± 3.9
SE + 100 mg/kg BI1029539	103.8 ± 5.3	95.5 ± 3.6

Data were normalized to β-actin levels; values are given as the percentage of control ± sem (n = 3). See Fig. 7A.

^*P < 0.01 for each endpoint compared with control (Dunnett’s many-to-one t test).