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. 2019 Nov 25;33(12):13617–13631. doi: 10.1096/fj.201901123R

Figure 7.

Figure 7

PQQ treatment improves lung mechanics of APN−/− ALI mice. A) Lung resistance (Rrs) measured by flexiVent at bsl and after LPS-induced ALI in APN−/− mice treated with and without PQQ; n = 6 in each group. B) Lung elastance (Ers); n = 6 in each group. C) Lung compliance (Crs); n = 6 in each group. D) Schematic illustration of the proposed sequence of events in APN-deficient mice that leads to mitochondrial dysfunction and impaired mitophagy, which together activate lung endothelium and predispose to injury in response to LPS. The restoration of mitochondrial biogenesis by PQQ treatment establishes endothelial homeostasis and attenuates LPS-induced ALI in APN-deficient mice. Ns, not significant. *P < 0.05, **P < 0.01, ***P < 0.001.