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. 2019 Sep 26;33(12):13280–13293. doi: 10.1096/fj.201901002R

Figure 1.

Figure 1

HCD worsened cognitive performance, whereas treatment with SV and EX maintained cognitive abilities. A–D) There was no strong adverse effect of HCD on the spatial MWM in either cohort 1 (A, B) or cohort 2 (C, D) in either WT or TGF mice. E, F) However, there was a clear trend in both cohorts for the HCD to worsen object recognition memory and for SV to prevent the decline (E), whereas mice that exercised reach cognitive performance comparable to that of WT mice (F). *P < 0.05, **P < 0.01.