Skip to main content
. 2019 Sep 26;33(12):13280–13293. doi: 10.1096/fj.201901002R

Figure 2.

Figure 2

The number of immature neurons in the dentate gyrus increased with SV and EX. A) In cohort 1, mice injected with BrdU to label newborn cells (small arrows) in the dentate gyrus (DG) of the hippocampus, a significant decrease in BrdU-positive cells was found in TGF and TGF HCD mice, whereas SV and EX groups were in between WT controls and untreated TGF groups, indicating a protective effect. C) Similar results were seen in cohort 2 when proliferating cells were labeled for Ki67. B, D) Staining for immature neurons in the DG revealed that all TGF groups had fewer positively labeled DCX cells, which was further decreased by HCD and protected by SV and EX in cohort 1 (B), but no such effects were seen in mice from cohort 2 with limited EX (D). Scale bars, 100 μm for BrdU (5 μm for inset) and 100 μm for Ki67 and DCX images (n = 4–5 mice/group). *P < 0.05, **P < 0.01, ***P < 0.001.