TABLE 1.

Plasma and brain cholesterol levels in mice from cohort 1

Variable	WT	TGF	TGF HCD	TGF HCD SV	TGF HCD EX
LDL (mM)	0.12 ± 0.01	0.11 ± 0.02	1.69 ± 0.47*	2.06 ± 0.33**	1.36 ± 0.19*
HDL (mM)	2.57 ± 0.16	2.40 ± 0.12	2.60 ± 0.27	2.75 ± 0.58	2.79 ± 0.14
Total cholesterol (mM)	2.57 ± 0.16	2.77 ± 0.12	4.55 ± 0.23***	5.05 ± 0.25***	4.52 ± 0.26***
Brain cholesterol (µg/100 µg cortex)	1.25 ± 0.05	1.23 ± 0.09	1.29 ± 0.24	1.48 ± 0.29	1.32 ± 0.09

Data are means ± sem. Serum samples spun down from peripheral blood samples acquired prior to perfusion were analyzed for LDL, HDL, and total cholesterol. A 10-mg piece of cortex was dissected from brains used for reactivity experiments to measure total cholesterol (n = 4–5/group). *P < 0.05, **P < 0.01, ***P < 0.001, indicate differences between group fed an HCD and groups fed a standard diet.