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. 2019 Nov 5;33(12):13126–13130. doi: 10.1096/fj.201901942R

TABLE 1.

Concentrations of EC and IC inorganic ions in heart, liver, and red blood cells

Perfused beating heart
Liver
Red blood cell,
control
Ion/location
Glucose
G + insulin
G + ketones
Control
+ Na acetate
Ca2+ EC 1.1 1.1 1.1 1.1 1.07 1.07
Ca2+ IC 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002
Na+ EC 144 144 149 146 ± 1 170 ± 2 144
Na+ IC 6.5 ± 5.2 5.6 ± 1.8 5.1 ± 0.8 12.3 ± 1.2 10.7 ± 1.5 8.8 ± 6.3
Mg2+ EC 0.5 0.5 0.5 0.52 ± 0.0 0.51 ± 0.02 0.52 ± 0.02
Mg2+ IC 1.2 ± 0.03 0.72 ± 0.3 0.74 ± 0.1 0.43 ± 0.0 0.97 ± 0.01 0.5
pH external 7.42 7.39 7.4 7.37 ± 0.03 7.52 ± 0.0 7.40
pH internal 7.06 ± 0.01 7.05 ± 0.2 7.04 ± 0.03 7.12 ± 0.07 7.12 ± 0.1 7.29 ± 0.0
K+ EC 5.9 5.9 5.9 5.22 ± 0.1 3.9 ± 0.3 5.16 ± 0.3
K+ IC 142 ± 3 147 ± 5 141 ± 6 175 ± 1 229 ± 2 153 ± 5
Cl EC 127 127 127 103 ± 1 95.4 ± 1 108 ± 1
Cl IC 47.9 ± 3.6 29.4 ± 5.5 36.1 ± 11 36.7 ± 2.3 30.8 ± 2.2 83.4 ± 2.9
HCO3 EC 25 25 25 26.7 ± 0.5 36.5 ± 1.4 26.7 ± 0.5
HCO3 IC 14.3 ± 0.2 14.4 ± 0.5 12 ± 0.4 15.1 ± 1.1 19.0 ± 1.6 22 ± 0.7
H2PO4 EC 0.18 0.19 0.19 0.22 ± 0.01 0.11 ± 0.01 0.39 ± 0.01
H2PO4 IC 2.43 ± 0.2 1.8 ± 0.2 2.9 ± 0.2 0.356 ± 0.08 0.48 ± 0.01 0.27 ± 0.02
HPO42− EC 0.91 0.90 0.91 0.95 ± 0.03 0.67 ± 0.04 1.9 ± 0.1
HPO42− IC 5.4 ± 0.4 4.03 ± 0.3 6.26 ± 0.4 0.91 ± 0.2 1.55 ± 0.45 1.0 ± 0.1

The values are given as means ± SEM in units of micromoles per milliliter. H2O free intracellular [Ca2+] was assigned as 0.2 μM in all tissues (11). EC, extracellular; IC, intracellular.