Figure 7.

Physiologic testing. Female mice of the indicated genotypes were subjected to CLAMS analysis 2 wk after conclusion of 1-wk treatment with dox. The indicated characteristics were statistically significant (α = 0.05). Genotype abbreviations are as in Fig. 3. Characteristics not found to have statistically significant differences include rearing activity, food intake, RER, and treadmill endurance. The fat body mass, resting energy expenditure (EE), active EE, and total EE comparisons were found to be statistically significant by paired Student’s t test (α = 0.05). Total activity and ambulation analysis was by 2-way ANOVA with Tukey’s test over genotype and time. Animal numbers were F + Cx (5), FFCx (5).