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. 2019 Dec 4;21:137. doi: 10.1186/s13058-019-1229-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Representative images of a patient with CTC clusters. Shown are representative images of a patient with CTC clusters with nuclear (DAPI) and cytokeratin (CK-PE) staining. CD45 stains for non-CTC leukocytes. HER2/neu staining further distinguished CTCs from leukocytes in this patient. This sample was associated with the following ctDNA genomic alterations: CDH1, TP53, NF1, PIK3CB, BRCA1, CCND1, CDK6, FGFR1, MET, and MYC