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. 2019 Dec 5;12:71. doi: 10.1186/s13072-019-0316-3

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Methylation DIY. a cg07640666, cg17353896, and cg24324379 are hyper-methylated in IDH1 mutation group in LGG (M value, p value < 0.05). b Major stage plot showing cg10983544 (TRIM58) is much hyper-methylated in stage II lung squamous cell carcinoma (M value, p value = 0.016). c cg04902327 (TRIM58) shows a lower level of methylation with low-level copy number amplification, whereas the other CpGs of TRIM58 show a positive correlation with CNV in lung squamous cell carcinoma (M value, p value < 0.05). − 2: homozygous deletion; − 1: single copy deletion; 0: diploid normal copy; + 1: low-level copy number amplification; + 2: high-level copy number amplification