Table 5.
Characteristics at diagnosis of FEP patients by cluster
| Symptom clusters | p value† | |||
|---|---|---|---|---|
| NMSC patients (n = 1487) | ASC patients (n = 1220) | MSC patients (n = 338) | ||
| Type of psychosis, n (%)‡ | < 0.0001 | |||
| Non-affective | 1023 (68.8) | 819 (67.1) | 194 (57.4) | |
| Drug-induced | 305 (20.5) | 277 (22.7) | 96 (28.4) | |
| Affective | 146 (9.8) | 117 (9.6) | 46 (13.6) | |
| Male, n (%) | 1064 (71.6) | 727 (59.6) | 123 (36.4) | < 0.0001 |
| Age, median (IQR) | 29 (21, 38) | 31 (24, 38) | 33 (25, 41) | < 0.0001 |
| Year of the index date, median (IQR) | 2010 (2007, 2013) | 2010 (2007, 2013) | 2010 (2007, 2012) | NS |
| Geographical region, n (%) | < 0.0001 | |||
| London | 158 (10.6) | 92 (7.5) | 21 (6.2) | |
| South England | 406 (27.3) | 300 (24.6) | 92 (27.2) | |
| Midlands and East England | 274 (18.4) | 249 (20.4) | 76 (22.5) | |
| North England | 243 (16.3) | 236 (19.3) | 53 (15.7) | |
| Northern Ireland | 53 (3.6) | 92 (7.5) | 23 (6.8) | |
| Scotland | 189 (12.7) | 125 (10.3) | 42 (12.4) | |
| Wales | 164 (11.0) | 126 (10.3) | 31 (9.2) | |
| Smoking, n (%) | 0.022 | |||
| Non-smoker | 495 (33.3) | 387 (31.7) | 129 (38.2) | |
| Ever smoker | 802 (53.9) | 768 (63.0) | 194 (57.4) | |
| Unknown | 190 (12.8) | 65 (5.3) | 15 (4.4) | |
| Alcohol consumption, n (%) | 0.005 | |||
| Non-drinker | 155 (10.4) | 112 (9.2) | 31 (9.2) | |
| Ever drinker | 730 (49.1) | 777 (63.7) | 235 (69.5) | |
| Unknown | 602 (40.5) | 331 (27.1) | 72 (21.3) | |
| Body mass index, median (IQR) | 23.4 (20.9, 27.1) | 23.8 (21.0, 28.1) | 25.0 (21.3, 30.2) | < 0.0001 |
| < 18.5 kg/m2 (underweight), n (%) | 65 (4.4) | 61 (5.0) | 24 (7.1) | |
| ≥ 18.5 kg/m2 and < 25 kg/m2 (normal), n (%) | 502 (33.8) | 460 (37.7) | 123 (36.4) | |
| ≥ 25 kg/m2 and < 30 kg/m2 (overweight), n (%) | 215 (14.5) | 215 (17.6) | 71 (21.0) | |
| ≥ 30 kg/m2 (obese), n (%) | 125 (8.4) | 154 (12.6) | 76 (22.5) | |
| Unknown, n (%) | 580 (39.0) | 330 (27.1) | 44 (13.0) | |
| Number of different prescriptions in 5 years before diagnosis, median (IQR) | 3 (2, 5) | 5 (3, 7) | 7 (5, 8) | < 0.0001 |
| Number of GP consultations in 5 years before diagnosis, median (IQR) | 36 (19, 65) | 66 (42, 103) | 119 (79, 171) | < 0.0001 |
| 4–5 years prior to diagnosis | 4 (1, 10) | 8 (3, 17) | 15 (8, 27) | < 0.0001 |
| 3–4 years prior to diagnosis | 4 (1, 11) | 9 (3, 18) | 18 (9, 33) | < 0.0001 |
| 2–3 years prior to diagnosis | 5 (1, 11) | 10 (4, 20) | 21 (11, 33) | < 0.0001 |
| 1–2 years prior to diagnosis | 6 (2, 13) | 13 (5, 22) | 21 (12, 40) | < 0.0001 |
| 0–1 year prior to diagnosis | 11 (5, 21) | 21 (11, 33) | 32 (19, 52) | < 0.0001 |
FEP first episode psychosis, NMSC no or minimal symptom cluster, ASC affective symptom cluster, MSC multiple symptom cluster, NS not significant
†Obtained from chi-squared or univariable multinomial logistic regression analysis as appropriate, and where applicable analysis excluded the unknown category (missing data)
‡Data were not reported for pregnancy-related psychosis due to CPRD reporting policy that no cell should contain fewer than five events