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. 2019 Dec 4;14:220. doi: 10.1186/s13014-019-1423-9

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Induction of the bystander and abscopal effects by time-synchronized immune-guided SBRT-PATHY: Figure shows a very voluminous lymph node metastasis of the left neck in metastatic melanoma patient, with a maximum diameter of 10 × 7 cm before SBRT-PATHY (red arrow, upper image left), as well as one additional lymph node metastasis with a maximum diameter 2 × 2 cm that was not irradiated (red arrow, lower image left). A dramatic regression of the partially treated bulky lesion and also of unirradiated smaller lymph node metastasis was observed 4 weeks later (green arrows, upper and lower images right)