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. 2019 Dec 4;24:68. doi: 10.1186/s11658-019-0190-9

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The effect of the miR-214–PD-L1 axis on the malignant behavior of OCI-Ly3 cells and on the cytokine secretion from T cells. (a and b) The expression of PD-L1 protein was determined using western blot. (c) The proliferation of OCI-Ly3 cells was determined using the CCK-8 assay. (d) The invasion ability of OCI-Ly3 cells was assessed using the Transwell assay (magnification, × 40). (e) The rate of OCI-Ly3 cell apoptosis was measured using flow cytometry. (f through h) The expression levels of TNF-α, IFN-γ and IL-10 were measured using ELISA. si-PD-L1: PD-L1 siRNA; si-PD-L1 + inh: PD-L1 siRNA + miR-214 inhibitor. *p < 0.05, **p < 0.01, compared with the NC group; ^#p < 0.05, ^##p < 0.01, compared with the si-PD-L1 group