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. 2019 Dec 4;7:340. doi: 10.1186/s40425-019-0772-0

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — ADU-1805 can be safely administered intravenously in NHPs. a ADU-1805 single-dose pharmacokinetics profile in NHPs. Target-mediated drug disposition (TMDD) observed at the lowest dose. Dose proportional increase in exposure for the two higher dose levels (e.g. 3.0 mg/kg and 30 mg/kg). b ADU-1805 does not affect hemoglobin (Hb) levels in cynomolgus monkeys. Vertical dashed lines indicate infusion of monkeys on day 0. The shaded bar indicates the range of hemoglobin typically requiring a transfusion in humans [40]. (a, b: n = 6 animals)