Table 2.

Study setup of the ADU-1805 non-GLP pilot toxicity study in 5–7 years old cynomolgus monkeys. A single dose of ADU-1805 or vehicle was administered i.v. for a duration of 15 min. Vehicle refers to the antibody formulation buffer: 10 mM L-Histidine pH 5.5 containing 0.1 M sodium chloride

Group	Treatment	Dose	Animals
1	Vehicle	–	1 male / 1 female
C2	ADU-1805	0.3 mg/kg	1 male / 1 female
3	ADU-1805	3 mg/kg	1 male / 1 female
4	ADU-1805	30 mg/kg	1 male / 1 female