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. 2019 Dec 4;21:136. doi: 10.1186/s13058-019-1208-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Invasive lobular cancer in a 49-year-old, with biopsy-proven invasive lobular cancer, grade 2. a Dynamic contrast-enhancement MRI maximum intensity projection of the left breast shows in the upper-outer quadrant, a 63-mm segmental area of non-mass enhancement, with heterogeneous internal enhancement pattern. b Diffusion-weighted sequence at b 850 and c apparent diffusion coefficient (ADC) map. d Among the three segmentation tools, the darkest part of the tumor (Dptu) 2D region of interest (ROI) proved to yield the highest diagnostic accuracy, showing the lowest ADC values (Dptu ADC mean, 1.021 × 10⁻³ mm²/s; whole tumor ROI, 1.568 × 10⁻³ mm²/s; point tumor delineation ROI, 1.029 × 10⁻³ mm²/s)