Table 3.

ADC values for all lesions and p values for the three different ROI placement approaches

ADC metric (× 10−3 mm2/s)	Benign (n = 27)	Malignant (n = 39)	Reading 1 (p values)	Benign (n = 27)	Malignant (n = 39)	Reading 2 (p values)
Wtu ADC max (reader 1)	2.126 (0.254–2.988)	2.523 (198–4095)	0.01*	2.318 (1.930–3085)	2.311 (1.466–2.968)	0.66
Wtu ADC max (reader 2)	2.395 (1.881–3.568)	2.563 (1.620–4.095)	0.12	2.302 (1.552–3.069)	2.323 (1.649–2.974)	0.86
Wtu ADC mean (reader 1)	1.273 (0.118–1.898)	1.372 (0.129–2.668)	0.50	1.392 (1.004–1980)	1.281 (0.726–1.794)	0.19
Wtu ADC mean (reader 2)	1.377 (0.935–2028)	1.356 (0.846–2020)	0.68	1.462 (1.005–2.141)	1.273 (0.870–1.630)	0.02
Wtu ADC min (reader 1)	0.225 (0–1.671)	0.195 (0–1.071)	1	0.180 (0–0.731)	0.187 (0–1.188)	0.90
Wtu ADC min (reader 2)	0.137 (0–1.194)	0.099 (0–0.970)	0.11	0.356 (0–1.353)	0.140 (0–1.146)	0.03*
Dptu ADC max (reader 1)	1.654 (0.254–2.438)	1.607 (0.139–2.814)	0.60	1.711 (1.143–2.617)	1.469 (0–2.763)	0.08*
Dptu ADC max (reader 2)	1.702 (0.438–2.379)	1.494 (0.053–2.825)	0.02	1.721 (1.103–2.686)	1.501 (0.687–2.370)	0.03
Dptu ADC mean (reader 1)	1.249 (0.252–2.176)	1.201 (0.012–1.942)	0.85	1.306 (0.970–2.463)	1.122 (0.619–1.761)	0.048*
Dptu ADC mean (reader 2)	1.996 (0.303–2.009)	1.154 (0.044–2.363)	0.06*	1.442 (0.780–2.280)	1.183 (0.601–1.744)	0.004*
Dptu ADC min (reader 1)	0.824 (0–1.904)	0.913 (0–2.048)	0.17	0.916 (0–2.249)	0.818 (0–1.670)	0.35
Dptu ADC min (reader 2)	0.871 (0–2.059)	0.839 (0–1.994)	0.75	1.402 (0.120–9.191)	0.848 (0–1.476)	0.02
Ptu ADC mean (reader 1)	1.127 (0–1.946)	1.324 (0.200–6.876)	0.56	1.238 (0.470–1.963)	1.144 (0.540–2.174)	0.19
Ptu ADC mean (reader 2)	1.512 (0.281–10.005)	1.018 (0.284–1.942)	0.206	1.661 (0.808 10.003)	1.057 (0.496–1.571)	0.001*

ADC apparent diffusion coefficient, Wtu, whole tumor, Dptu darkest part of the tumor, Ptu point tumor

*Denotes a statistical significance