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. 2019 Dec 4;10:373. doi: 10.1186/s13287-019-1486-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Force-frequency relationship. a Force-frequency response normalized to 0.25-Hz baseline for individual hECTs, with mean ± SD for control (red circle, n = 13) and hCSC-supplemented (blue triangle, n = 10) hECT groups. The regression slope for control hECTs was different from zero (p = 0.013) whereas the hCSC-supplemented slope was not (p = 0.067). b Force-frequency response of individual hECTs from hCM-only control (solid lines) and hCSC-supplemented (dashed lines) groups. hECTs that lost 1:1 capture below 1.0 Hz are indicated by abbreviated curves. c, d Example twitch tracings for hCM-only control (c) and hCSC-supplemented (d) hECTs at 0.25-Hz (black line) and 1.0-Hz pacing (gray line)