TABLE 1.

Definitions of Screening Strategies

Screening strategy designation	Screening strategy description	Definition of positive imaging result	After positive imaging results	After negative imaging results
1	Standard biopsy	N/A (no imaging)	N/A; always standard biopsy	N/A; always standard biopsy
2	mpMRI alone (Likert scores)	Likert 4–5	Combined biopsy	Standard biopsy
3	mpMRI alone (PI-RADS scores)	PI-RADSv2 3–5	Combined biopsy	Standard biopsy
4	18F-choline PET/mpMRI (Likert scores)	Likert 5 mpMRI lesion or Likert 3–4 mpMRI lesion with 18F-choline TBR of ≥1.58*	Combined biopsy	Standard biopsy
5	18F-choline PET/mpMRI (PI-RADS scores)	PI-RADS 5 mpMRI lesion or PI-RADS 3–4 mpMRI lesion with 18F-choline TBR of ≥1.58	Combined biopsy	Standard biopsy
6	mpMRI alone (Likert scores)	Likert 4–5	Combined biopsy	No biopsy
7	mpMRI alone (PI-RADS scores)	PI-RADS 3–5	Combined biopsy	No biopsy
8	18F-choline PET/mpMRI (Likert scores)	Likert 5 mpMRI lesion or Likert 3–4 mpMRI lesion with 18F-choline TBR of ≥1.58	Combined biopsy	No biopsy
9	18F-choline PET/mpMRI (PI-RADS scores)	PI-RADS 5 mpMRI lesion or PI-RADS 3–4 mpMRI lesion with 18F-choline TBR of ≥1.58	Combined biopsy	No biopsy

^*TBR threshold was defined in study by Piert et al. (8).

N/A = not applicable.