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Time–activity curves (average SUV ± SD) for 18F-MitoPhos in Sprague–Dawley rats for left ventricle. SUVs are displayed over duration of scan (A) and for first minute (B). Significant decrease in cardiac uptake for both 15 mg/kg and 20 mg/kg dose in myocardium is observed. Statistical analysis was 2-way ANOVA and Dunnett post hoc analysis. ***P < 0.001 for control compared with doxorubicin (DOX), 20 mg/kg. ††P < 0.01 for control compared with doxorubicin, 15 mg/kg.
