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. Author manuscript; available in PMC: 2019 Dec 5.
Published in final edited form as: J Hum Genet. 2018 Jan 30;63(4):431–446. doi: 10.1038/s10038-017-0403-x

Fig. 2.

Fig. 2

Heat map of the enrichment of lncRNA SNPs in the potential regulatory regions. This heat map was constructed by calculating the percentage of 55 lncRNA SNPs and their proxies in strong LD (R2>0.8) located in DNA regulatory regions as defined by the chromatin states using the Roadmap epigenomes data set across tissues relevant to cardiovascular disease (e.g., aorta, fetal heart, atrium, and ventricle), metabolic disorders (e.g., liver, pancreas, and adipose), and also control tissues (e.g., lung and brain). The lncRNA SNPs which are top variants in their loci associated with cardiometabolic disorders are shown in bold. As shown, almost all SNPs are not over-represented in the regulatory regions related to cardiometabolic disorders. Rs4841132 in lncRP11–10A14.4 (LOC157273) was the only SNP that the (potential) regulatory region, in which the SNP is located, was enriched for the relevant cell type (liver).