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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: J Mol Cell Cardiol. 2019 Sep 7;136:42–52. doi: 10.1016/j.yjmcc.2019.09.002

Figure 10. HcTnI-C27 reduces Ca2+ sensitivity of skinned mouse cardiac muscle.

Figure 10.

The Force-pCa curves show that HcTnI-C27 treatment decreased Ca2+-sensitivity of skinned mouse ventricular papillary muscle at sarcomere lengths (SL) of 2.0 μm (A) and 2.3 μm (B) with decreased cooperativity (n) at SL of 2.0 μm. The maximum force production was not significantly affected by the addition of HcTnI-C27 peptide (the bar graphs). Ca50, Ca2+ concentration for 50% maximum force. Values are presented as mean ± SE. N = 3 for 2.0 μm and n = 4 for 2.3 μm groups. Statistical analysis was done using paired Student’s t test. *P < 0.05 vs the HcTnI-C27 peptide-absent baseline.