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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: J Mol Cell Cardiol. 2019 Sep 7;136:42–52. doi: 10.1016/j.yjmcc.2019.09.002

Figure 11. Ca2+-desensitization effect of HcTnI-C27 peptide in skinned mouse EDL muscle.

Figure 11.

Force-pCa curves of skinned EDL muscle fibers at sarcomere length (SL) of 2.7 μm in the absence or presence of 20 μM HcTnI-C27 peptide showed a decrease in cooperativity (n) upon HcTnI-C27 treatment due to the decreases in myofilament Ca2+ sensitivity in the activated state at higher Ca2+ concentrations without change of maximum force production. Values are presented as mean ± SE. N = 4 in each group. *P < 0.05 vs the baseline in one-tail Student’s t test.