Aβ and IL6 influenced the relationship between NODDI metrics and clustering coefficient. Values for intracellular volume fraction and orientation dispersion are negatively correlated with the clustering coefficient in fimbria, hippocampus, and cerebral peduncle. Shown are individual data points for nTg-controls (black circles), nTg-IL6 (red circles), Tg-controls (orange circles), and Tg-IL6 (green circles). Statistical p values indicate a significant non-zero slope (99% confidence intervals shown).