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Brain expression of IL6 resulted in widespread gliosis. A) Analysis of astrocytosis (GFAP, A-B), microgliosis (Iba-1, C-D) and IL6 protein (G) in nTg mice demonstrate that IL6 expression leads to dramatic upregulation of immune response throughout the brain. E-F) Show myelin basic protein (MBP) is not altered by IL6. HPC, hippocampus; CTX, cortex; STR, Striatum; MID; midbrain. B-D. One-way ANOVA, *p<0.05; **p<0.01, ***p<0.005, n=6; E. Student’s t test, **p<0.01, n=4.
