Table 1.

Statistically significant ≥10% decreases of 9 cytokines in the dexmedetomidine group

Cytokine	Baseline pg/ml [median (IQR)]	Anesthesia pg/ml [(median (IQR)]	Unadjusted p-value	Adjusted p-value
MCP-1	40 (16)	30 (12)	< 0.001	< 0.001
CTACK	776 (171)	608 (227)	< 0.001	0.002
MIF	180 (160)	123 (160)	< 0.001	< 0.001
Eotaxin	77 (52)	64 (48)	< 0.001	< 0.001
SCF	64 (15)	56 (16)	< 0.001	< 0.001
IL-18	44 (22)	36 (15)	0.012	0.038
IL-2rα	42 (17)	34 (12)	0.006	0.018
VEGF	54 (62)	47 (42)	0.016	0.04
SCGF	16,305 (4218)	13,006 (4003)	< 0.001	< 0.001

Data were analyzed using nonparametric testing due to the skewed distributions and the outlying observations. The median as well as the inter quartile range (IQR) values are reported for each cytokine. The unadjusted p-values were calculated using Wilcoxon signed rank test and the adjusted p-values were calculated using Benjamini-Hochberg method (42 hypothesis tests) controlling for a false discovery rate at 0.05