Table 3.
Risk Reclassification Table of 10‐Year Major Osteoporotic Fracture (MOF) and Hip Fracture Stratified by Event Statusa
| Outcome | Model containing only FRAX score | Model containing FRAX score and additional variablesb | ||
|---|---|---|---|---|
| Hip fracture | Frequency (row %) | <3% risk | ≥3% risk | Total |
| Participants with an event | ||||
| <3% risk | 947 (72.4) | 361 (27.6) | 1308 | |
| ≥3% risk | 91 (13.6) | 579 (86.4) | 670 | |
| Total | 1038 | 940 | 1978 | |
| Participants without an event | ||||
| <3% risk | 76,119 (91.2) | 7381 (8.8) | 83,500 | |
| ≥3% risk | 1906 (28.9) | 4691 (71.1) | 6597 | |
| Total | 78025 | 12072 | 90,097 | |
| Major osteoporotic fracture | Frequency (row %) | <20% risk | ≥20% risk | Total |
| Participants with a MOF event | ||||
| <20% risk | 8558 (89.9) | 959 (10.1) | 9517 | |
| ≥20% risk | 291 (13.3) | 1902 (86.7) | 2193 | |
| Total | 8849 | 2861 | 11,710 | |
| Participants without a MOF event | ||||
| <20% risk | 74,081 (96.4) | 2747 (3.6) | 76,828 | |
| ≥20% risk | 1332 (22.7) | 4543 (77.3) | 5875 | |
| Total | 75,413 | 7290 | 82,703 | |
a
Net reclassification index (NRI) for cases:
Hip fracture: (361–91)/1978 = 0.137; MOF: (959–291)/11710 = 0.057.
NRI for noncases:
Hip: (1906–7381)/90097 = −0.061; MOF: (1332–2747)/82703 = −0.017.
b
Treated diabetes, ≥two falls in the past year, vasomotor symptoms, physical function score.
All models are adjusted by Women's Health Initiative Hormone and Calcium Vitamin D Trial intervention status (active, placebo, not randomized).
FRAX = Fracture risk assessment tool.