Table 1. Mouse: First estimations of SPR variability and the errors introduced by linearization and loss of spatial resolution.

Deterministic simulations with R* lifetimes τ_av and 2τ_av, using the FSR, TWS and GWS models. Δ% is the relative difference of the outputs for each pair of runs. Computation of ${\text{E}}_{\text{area}}^{*}$, and the maximum value ${\text{E}}_{\text{max}}^{*}$ of E*(t), as defined by Eqs 14 and 15, for each of these two runs. Computation of I(t_peak) using the nonlinear relations Eqs 1 and 2 and I_lin(t_peak) using the linearization Eq 17 for the cGMP component of the current and the nonlinear relation Eq 2 for J_ex. ${\text{E}}_{\text{max}}^{*}$, ${\text{E}}_{\text{area}}^{*}$ and ${\mathcal{G}}_S\left({\text{t}}_{\text{peak}}\right)$ are independent of the linearization Eq 17.

	FSR model, DcG = 120 μm2/s
	${\text{E}}_{\text{max}}^{*}$	${\text{E}}_{\text{area}}^{*}\left(\text{s}\right)$	${\mathcal{G}}_S\left({\text{t}}_{\text{peak}}\right)\%$	I(tpeak)%	Ilin(tpeak)%	Iarea(s)	Iarea;lin(s)
τav	9.51	2.112	1.799	5.49	6.22	1.556	1.687
2τav	15.24	4.266	2.430	7.09	8.40	2.448	2.735
Δ%	60.2	102.0	35.1	29.1	35.0	57.3	62.1
	FSR model, DcG = 330 μm2/s
τav	6.83	1.517	1.722	5.54	5.96	1.466	1.536
2τav	10.95	3.063	2.612	8.12	9.04	2.522	2.707
Δ%	60.3	101.9	51.7	46.6	51.7	72.0	76.2
	TWS model, DcG = 120 μm2/s
τav	9.51	2.112	2.057	6.14	7.11	1.692	1.854
2τav	15.24	4.266	2.878	8.10	9.94	2.712	3.089
Δ%	60.2	102.0	39.9	31.9	39.8	60.3	66.6
	TWS model, DcG = 330 μm2/s
τav	6.83	1.517	1.783	5.72	6.17	1.514	1.588
2τav	10.95	3.063	2.756	8.51	9.54	2.634	2.838
Δ%	60.3	101.9	54.6	48.8	54.6	74.0	78.7
	GWS model
τav	9.51	2.112	2.857	9.56	9.90	2.446	2.502
2τav	15.24	4.266	4.874	15.91	16.89	4.614	4.796
Δ%	60.2	102.0	70.6	66.4	70.6	88.6	91.7