Table 5. Mouse.

CV for I(t_peak) and I_area by the FSR, TWS and GWS models, for D_cG = 120 μm²/s and D_cG = 330 μm²/s. CVs computed for the WT mouse and the following virtual conditions. LIN: i.e., the nonlinear fluxes Eqs 10–12 were linearized. NLD (non-local depletion): i.e., in the product [E*]_σ[cGMP] in the last term on the right hand side of Eq 9, [cGMP] were kept constant at its dark value. LIN+NLD: both effects are enforced. Ca²⁺-clamp: Ca²⁺ dependence of cyclase activity was removed, i.e., in the expression of F in Eq 10, [Ca²⁺] was kept at its dark value [Ca²⁺]_dark. In all cases $\text{CV}\left({\text{E}}_{\text{max}}^{*}\right)=0.45$ and $\text{CV}\left({\text{E}}_{\text{area}}^{*}\right)=0.56$.

	CV[I(tpeak)]	CV(Iarea)(s)
FSR	DcG = 120 μm2/s
WT	0.29	0.38
LIN	0.36	0.44
NLD	0.37	0.42
LIN+NLD	0.52	0.56
Ca2+-clamp	0.34	0.38
FSR	DcG = 330 μm2/s
WT	0.38	0.44
LIN	0.44	0.50
NLD	0.43	0.47
LIN+NLD	0.52	0.56
Ca2+-clamp	0.43	0.46
TWS	DcG = 120 μm2/s
WT	0.32	0.39
LIN	0.40	0.47
NLD	0.37	0.42
LIN+NLD	0.52	0.56
Ca2+-clamp	0.36	0.40
TWS	DcG = 330 μm2/s
WT	0.41	0.46
LIN	0.47	0.52
NLD	0.44	0.48
LIN+NLD	0.53	0.56
Ca2+-clamp	0.45	0.47
GWS	GWS
WT	0.47	0.51
LIN	0.51	0.55
NLD	0.49	0.52
LIN+NLD	0.52	0.56
Ca2+-clamp	0.49	0.51