Table 1. ADME properties for Pyronaridine tetraphosphate.

Pyronaridine
ADME property	Data
Solubility	168 μM at pH 7.4
CYP inhibition	1A2, 2C9, 2C19 (>50 μM), 3A4 (42.9 μM), 2D6 (2.23 μM)
Mouse liver microsomes	t1/2 = 173 min, CLint = 4 μL/min/mg protein
Guinea Pig liver microsomes	t1/2 = 44.4 min, 15.6 μL /min/mg protein
Non-Human primate liver microsomes	t1/2 = 140.1 min, 4.9 μL /min/mg protein
Human liver microsomes	T1/2 = 169.7 min, 4.1 μL /min/mg protein
Mouse plasma protein binding	96.5%
Human plasma protein binding	95.1%
Caco-2	Papp A-B = 6.46; B-A = 4.8 (x10-6 cm/s) Efflux ratio = 0.74
CYP3A4 Induction	1.5x at 10 μM