Table 2. Pharmacokinetics data in mice treated with pyronaridine.

NC = not calculated.

					Cmax (ng/ml)		AUClast (h*ng/ml)
Dose (mg/kg)	Sex	T1/2 (h)	SE	Tmax (h)	Mean	SE	Mean	SE	AUCinf (h*ng/ml)
5	M	NC		0.25	44.4	9.58	192	12.2	NC
5	F	NC		0.083	54	2.44	257	13.5	NC
25	M	NC		0.25	115	19.3	713	34.2	NC
25	F	NC		0.25	160	41.4	956	45.5	NC
75	M	146	12.7	1.†	982	242	33039	4731	33912