Table 3. Quantitative RT-PCR and Plaque Assay Results for Animals euthanized on SD3.
| SD3 | Group | Vehicle | Pyronaridine 50 mg/kg | Pyronaridine 75 mg/kg | Tilorone (30 mg/kg) |
|---|---|---|---|---|---|
| N | 6 | 12 | 12 | 6 | |
| RT-PCR (GEq/uL) | Geometric Mean | 6.74E+04 | 2.75E+03 | 6.53E+02 | 3.37E+03 |
| 95% CI | Lower 95% CI | 1.66E+04 | 8.86E+02 | 4.56E+02 | 2.17E+02 |
| Upper 95% CI | 2.73E+05 | 8.56E+03 | 9.35E+02 | 5.22E+04 | |
| Plaque (PFU/mL) | Geometric Mean | 7.39E+05 | 3.51E+04 | 9.13E+02 | 9.57E+03 |
| 95% CI | Lower 95% CI | 1.07E+05 | 8.97E+03 | 1.63E+02 | 1.11E+03 |
| Upper 95% CI | 5.10E+06 | 1.37E+05 | 5.12E+03 | 8.29E+04 |