Table 1:
Demographic and baseline characteristics of patients
| MISTIE (n=250) |
Medical (n=249) |
|
|---|---|---|
| Demographic variables | ||
| Age (years) | 62 (52–70) | 62 (53–71) |
| Men | 159 (63.6) | 146 (58.6) |
| Race | ||
| Black | 46 (18.4) | 41 (16·5) |
| White | 190 (76.0) | 184 (73·9) |
| Other | 13 (5.2) | 24 (9·6) |
| Unknown | 1 (0·4) | 0 (0·0) |
| Ethnicity: Hispanic/Latino | 34 (13·6) | 34 (13·7) |
| Baseline variables | ||
| Tobacco use | 50 (20·0) | 39 (15·7) |
| Cocaine use | 11 (4·4) | 9 (3·6) |
| Anticoagulated | 24 (9·6) | 10 (4·0) |
| Hormone replacement therapy | 1 (0·4) | 3 (1·2) |
| Hyperlipidaemia medication compliant | 96 (38·4) | 93 (37·4) |
| On antiplatelets | 67 (26·8) | 77 (30·9) |
| Diabetes | 72 (28·8) | 67 (26·9) |
| Hypertension | 241 (96·4) | 240 (96·4) |
| Other cardiovascular disease | 38 (15·2) | 34 (13·7) |
| GCS score at randomisation* | ||
| 3–8 | 64 (25·6) | 63 (25·3) |
| 9–12 | 111 (44·4) | 108 (43·4) |
| 13–15 | 75 (30·0) | 78 (31·3) |
| NIHSS score at randomisation | 19 (15–23) | 19 (15–23) |
| Diagnostic CT (at presentation) | ||
| ICH volume (mL) | 42·7 (30·4–54·5) | 41·5 (30·9–55·3) |
| IVH volume (mL) | 0 (0–1·7) | 0 (0–1·9) |
| Stability CT (prior to randomisation) | ||
| ICH volume (mL) | 45·8 (35·4–59·6) | 45·3 (35·4–57·2) |
| IVH volume (mL) | 0·3 (0–3·1) | 0·4 (0–3·2) |
| Ventilated at randomisation | 107 (42·8) | 102 (41.0) |
| Blood pressure at presentation | ||
| Systolic BP (mm Hg) | 177 (155–208) | 176 (158–200) |
| Diastolic BP (mm Hg) | 99 (85–113) | 98 (84–114) |
| Blood pressure at randomisation | ||
| Systolic BP (mm Hg) | 138 (130–148) | 138 (131–148) |
| Diastolic BP (mm Hg) | 70 (63–78) | 69 (60–77) |
| Ictus to diagnostic CT time (hours) | 2·2 (1·1–6·0) | 1·9 (1·2–4·8) |
| Ictus to stability CT time (hours) | 36·4 (23·4–52·6) | 36·3 (23·6–48·6) |
| Clot location: deep | 163 (65·2) | 144 (57·8) |
| mRS score before stroke | ||
| 0 | 230 (92·0) | 233 (93·6) |
| 1 | 20 (8·0) | 16 (6·4) |
Data are median (IQR) or n (%). Five patients in the MISTIE group and two patients in the control group were randomly assigned in error and thus were excluded. GCS=Glasgow Coma Scale. NIHSS=National Institutes of Health Stroke Scale. ICH=intracerebral haemorrhage. IVH=intraventricular haemorrhage. BP=blood pressure. mRS=modified Rankin Scale.
*
GCS scores range from 15 (fully conscious) to 3 (deep coma).