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. 2019 Nov 29;10:2777. doi: 10.3389/fmicb.2019.02777

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Copyright © 2019 Song, Wu, Cao, Yao and Long.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CFRs of achieving 50% fT > MIC, 50% fT > 2×MIC, and 50% fT > 5 × MIC for meropenem with various dosage regimens simulated for the targeted bacteria populations with pooled MIC distributions between 16 and 512 mg/L. AB, Acinetobacter baumannii; AS, Acinetobacter spp.; EFS, Enterococcus faecalis; EFM, Enterococcus faecium; PA, Pseudomonas aeruginosa; SE, Staphylococcus epidermidis; SHA, Staphylococcus haemolyticus; SM, Stenotrophomonas maltophilia; 50% fT > MIC, 50% of the dosing interval during which free drug concentrations remain above the MIC; 50% fT > 2 × MIC, 50% of the dosing interval during which free drug concentrations remain above the MIC by two-fold; 50% fT > 5 × MIC, 50% of the dosing interval during which free drug concentrations remain above the MIC by five-fold.