Table 1.
Quantification of histologic organization and maturity of scaffold-regenerated bones versus bone graft and native bone.
| Native Bone (95% CI) | Bone Graft (95% CI) | Scaffold Bone (95% CI) | p-valuea | |
|---|---|---|---|---|
| CALVARIUM | ||||
| Vessel Density (/mm2) | 0.27 (0.13–0.42) | 0.27 (0.07–0.47) | 0.19 (0.03–0.35) | 0.54 |
| Vessel Diameter (µm) | 36.9 (3.0–70.8) | 60.8 (31.7–89.8) | 52.2 (37.2–67.2) | 0.16 |
| Osteocyte Density (/mm2) | 157.3 (129.1–185.6) | 190.4 (143.9–237.0) | 157 (104.5–209.6) | 0.20 |
| Osteoblast Density (/mm2) | 0.65 (−0.89–2.20) | 2.61 (−3.16–8.38) | 3.92 (−1.20–9.04) | 0.29 |
| Osteoclast Density (/mm2) | 0.01 (−0.039–0.063) | 0.06 (−0.023–0.15) | 0.06 (−0.017–0.13) | 0.41 |
| Osteoblast/Osteoclast (ratio) | 54.69 | 41.71 | 68.60 | 0.44 |
| ALVEOLUS | ||||
| Vessel Density (/mm2) | 0.57 (0.22–0.93) | 0.63 (0.27–0.99) | 0.71 (0.29–1.14) | 0.72 |
| Vessel Diameter (µm) | 108.8 (87.9–129.8) | 82.6 (54.5–110.7) | 76.0 (12.4–139.6) | 0.20 |
| Osteocyte Density (/mm2) | 148.1 (141.9–154.3) | 166.5 (115.6–217.4) | 153.6 (121.6–185.6) | 0.50 |
| Osteoblast Density (/mm2) | 5.84 (−1.60–13.29) | 6.76 (−8.74–22.27) | 16.95 (−2.42–36.31) | 0.18 |
| Osteoclast Density (/mm2) | 0.11 (−0.080–0.31) | 0.06 (−0.043–0.16) | 0.26 (−0.017–0.53) | 0.21 |
| Osteoblast/Osteoclast (ratio) | 51.12 | 113.61 | 65.47 | 0.25 |
No statistically significant difference between scaffold-regenerated bone and bone graft or native bone in any of these features. CI = confidence Intervals. ap-value by one-way ANOVA.