Table 2.
Lactate/pyruvate ratio and the levels of glutamate, glycerol, lactate dehydrogenase, NO metabolites, and DHBA in BALF from the V + nonheated, V + heated (42 °C for 80 min), OT (20 μg/kg) + heated and L-368,899 + OT (20 μg/kg) + heated groups.
| Parameters | V + nonheated | V + heated | V + OT + heated | L-368,899 + OT + heated |
|---|---|---|---|---|
| 1. Glutamate (% of baseline) | 100 ± 18 | 422 ± 26b | 153 ± 23e | 430 ± 27d |
| 2. Lactate/pyruvate ratio (% of baseline) | 100 ± 9 | 199 ± 12b | 124 ± 11e | 207 ± 14d |
| 3. Glycerol (% of baseline) | 100 ± 8 | 185 ± 9b | 112 ± 6e | 199 ± 10d |
| 4. Nitric oxide metabolites (% of baseline) | 100 ± 11 | 453 ± 24b | 149 ± 19e | 463 ± 25d |
| 5. 2,3-Dihydroxybenzoic acid (% of baseline) | 100 ± 14 | 207 ± 22b | 138 ± 16e | 215 ± 23d |
The results are presented as the mean ± SD (N = 10). bP < 0.05 compared with the V + nonheated group; eP < 0.05 compared with the V + heated group; dP < 0.05 compared with the V + OT + heated group.
Rats were sacrificed 100 min after the initiation of heat stress by an overdose of anesthetic, and the samples were collected for biochemical determination.